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Differences in the function of the central nervous system and the brain-gut axis: Differences in the degree of dysfunction of the brain-gut axis (such as the activity of the central pain processing pathway) and functional differences in pain-regulating brain regions will lead to different analgesic and emotional regulation effects of VNS (23, 39)

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Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008